I would worry about the takedown lever not being firmly detained enough in the fire position to prevent it being nudged into interference with the slide or FC mechanism due to a firm or
frantic grip, or recoil, being that it seems to be right where the thumb would land. I assume, simply as the takedown lever, it would still need to be strongly held, possibly with a crisp and positive ball/pin detent, in the assembled position to avoid slide interference. Regardless, for California purposes, I would approach it as a legal necessity,
more functionally as a lockout than a carry safety.
I doubt anyone will consider it a viable carry safety due to ergos. You'd need a dedicated, ergonomically correct lever for that. I would just focus on making it secure in the fire position, yet trying to keep it one hand operable for administrative slide lock, with a strong spring detent at the halfway point so people don't overshoot the sweep during admin lockback
The only other realistic option I can think of would be to move the take down lever to the right side, then add a manual safety to the left side that would resemble a traditional slide lock lever and could double as an admin slide lock when pushed up a bit extra into "safe" with the slide back. This would add a significant protrusion if positive to use, though, as well as manufacturing cost. And it wouldn't suit everyone, whereas the slide takedown integration is ideal if done as a regulatory "trick" without interfering.
Thing is, even
if the witness hole is sufficient for a loaded chamber indicator, which it probably is not based on the
rules as of 2007 (pg 14), you may also end up dealing with the Cali DOJ deciding to move forward with requiring microstamping capability on all newly approved pistols. The date for implementation was supposed to be Jan 1, 2010, but it's been delayed for now over patent issues. If you get something worked out that doesn't compromise the design's stress/fumble-proofness and functional manners in time to have it approved before (if) they move forward, then you should be OK on the microstamping. Good news is, the California Police Chief's Association is calling for review of the concept and speaking poorly of it on functional and fiscal grounds
already, now that they're actually faced with the ramifications, even though they supported the law when it was passed. Go figure.
Also since 2007, Cali requires a magazine disconnect safety, which I'd say most people do not want. I'd suggest it be reasonably end-user removable. I know some pistols are designed with it as a removable option these days.